Studies on the Sensitization of Animals with Simple Chemical Compounds. Ii

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS VIII. SENSITIZATION TO PICRIC Acre; SvBsn)I~mY AGENTS AND MODE OF SENSITIZATION BY K. LANDSTEINER, M.D., AND A. A. DI SOMMA, PH.D

Studies on the Sensitization of Animals with Simple Chemical Compounds Ix. Skin Sensitization Induced by Injection of Conjugates

In experimental work on sensitization with a group of simple chemical substances, strong evidence was obtained for the view that the production of hypersensitivity depended upon the formation of antigenic combinations in the body (1). As a corollary, the direct administration of in vitro conjugates in these cases should lead to skin sensitivity towards the corresponding low molecular substance....

Nitric oxide mediation of morphine sensitization in the rat nucleus accumbens

Previous studies have reported that morphine exerts its effects in part through the release of nitric oxide (NO). It has been pustulated that drug sensitization is a major cause of relapse to drug use in addicts. In the present study the effects of intra-accumbal injections of L-arginine, the NO precursor and L-NAME, the NOS inhibitor on the morphine sensitization in Wistar rats (250-300 g) wer...

Synthesis and Metal Ion Uptake Studies of Silica Gel-Immobilized Schiff Base Derivatives and Catalytic Behaviors of their Cu(II) Complexes

New silica supported Schiff base ligands were prepared by the condensation reaction of 4,6-diacetylresorcinol with silica-gel derivatives, which modified with 3-aminopropyltriethoxysilane and N-(2-aminoethyl) -3-aminopropyltrimethoxysilane. Metal ion uptake capacities of these compounds were studied towards of selected transition metal (Cd(II), Cu(II), Co(II), Mn(II), Pb(II) and Ni(II)) cations...

Nitric oxide mediation of morphine sensitization in the rat nucleus accumbens

Previous studies have reported that morphine exerts its effects in part through the release of nitric oxide (NO). It has been pustulated that drug sensitization is a major cause of relapse to drug use in addicts. In the present study the effects of intra-accumbal injections of L-arginine, the NO precursor and L-NAME, the NOS inhibitor on the morphine sensitization in Wistar rats (250-300 g) wer...

Ascorbic acid inhibits nicotine-induced behavioral sensitization in male mice

Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...